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1 article(s) from Danneberg, Friederike

Sequence-specific RNA cleavage by PNA conjugates of the metal-free artificial ribonuclease tris(2-aminobenzimidazole)

Friederike Danneberg,
Alice Ghidini,
Plamena Dogandzhiyski,
Elisabeth Kalden,
Roger Strömberg and
Michael W. Göbel

Beilstein J. Org. Chem. 2015, 11, 493–498, doi:10.3762/bjoc.11.55

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Graphical Abstract

Scheme 1: Formation of the 2-aminobenzimidazole moiety.

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Scheme 2: Synthesis of tris(2-aminobenzimidazole). Conditions: a: Boc-ON, THF, 0 °C to rt, 46 h, 45%; b: 1) 1...

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Scheme 3: Synthesis of PNA conjugates. Conditions: a: 1) 9, HOBt, DIC, DMF, rt, 24 h; 2) piperidine, DMF, rt,...

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Figure 1: Sequences of PNA conjugates 10–14 and oligonucleotides 15–20. Lysines are attached to the C-terminu...

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Figure 2: Cleavage of RNA by their corresponding PNA conjugates (150 nM substrate, 750 nM conjugate, 50 mM Tr...

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Figure 3: Substrate specificity of conjugates 12 and 14 (150 nM substrate, 750 nM conjugate, 50 mM Tris-HCl, ...

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Figure 4: Cleavage of RNA substrates 15, 16, and 17 by their matching conjugates as a function of conjugate c...

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Figure 5: Cleavage kinetics of 15 in the presence and absence of conjugate 12. Conditions: 150 nM substrate, ...

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Published 16 Apr 2015

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